Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 87 58.68 64.87 56,166,354
Mutual Fund 79 5.47 6.66 5,768,066
Insider 2 0.30 0.14 122,178

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 52 49.11 54.00 46,757,050
Sellers 32 -3.20 3.36 -2,906,566
Net -- 45.91 50.64 43,850,484

Concentration

Value ($MM) % O/S Shares
Total Inst. 58.68 64.87 56,166,354
Top 10 Inst. 53.59 59.28 51,323,445
Top 20 Inst. 56.49 62.46 54,082,892
Top 50 Inst. 58.34 64.49 55,835,795

Style

Holders Value ($MM) % Inst Shares Shares
Growth 12 0.58 0.63 548,720
Core Growth 10 0.51 0.56 485,865
Growth 2 0.07 0.07 62,855
Income 3 0.17 0.19 166,349
Income Value 2 0.17 0.19 161,349
Yield 1 0.01 0.01 5,000
Index 14 8.47 9.32 8,071,174
Other 33 46.45 51.08 44,225,481
Broker Dealer 12 0.47 0.50 433,443
GARP 8 0.90 0.99 856,828
Hedge Fund 9 8.18 8.99 7,786,268
Specialty 1 -- -- 336
VC/Private Equi 3 36.91 40.59 35,148,606
Value 8 0.40 0.44 385,023
Core Value 6 0.12 0.13 115,855
Deep Value 2 0.28 0.31 269,168

Location: Global Region

Holders % O/S Shares Share Change
North America 77 61.80 53,511,163 46,024,307
Europe 4 0.33 288,918 189,756

Top Holders

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 25,000,000 28.87 25,000,000 3/31/18
Vivo Capital, LLC 8,180,000 9.45 8,180,000 3/31/18
BVF Partners L.P. 5,000,000 5.77 5,000,000 3/31/18
BlackRock Institutional Trust Company, N.A. 3,592,725 4.15 2,244,816 3/31/18
The Vanguard Group, Inc. 2,244,275 2.59 1,418,427 3/31/18
GlaxoSmithKline Plc 2,121,668 2.45 -- 1/19/18
Polaris Venture Partners 1,968,606 2.27 -- 3/31/18
Alyeska Investment Group, L.P. 1,834,804 2.12 1,834,804 3/31/18
Northern Trust Investments, Inc. 749,232 0.87 467,355 3/31/18
State Street Global Advisors (US) 632,135 0.73 261,200 3/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
iShares Russell 2000 ETF 1,886,094 2.18 87,694 5/31/18
Vanguard Total Stock Market Index Fund 846,497 0.98 -340,180 5/31/18
Vanguard Extended Market Index Fund 751,470 0.87 21,700 5/31/18
iShares Russell 2000 Growth ETF 605,910 0.70 35,990 5/31/18
CREF Stock Account 243,213 0.28 159,800 3/31/18
iShares Micro-Cap ETF 190,284 0.22 67,725 5/31/18
Fidelity Extended Market Index Fund 157,873 0.18 -- 4/30/18
AXA 2000 Managed Volatility Portfolio 116,872 0.13 -- 4/30/18
iShares Russell 2000 Value ETF 108,505 0.13 7,350 5/31/18
Vanguard Russell 2000 Index Fund 85,562 0.10 1,089 5/31/18

* Insider values reflect direct beneficial ownership.

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