Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 87 68.80 66.58 57,648,113
Mutual Fund 83 5.94 6.96 6,022,762
Insider 2 0.30 0.14 122,178

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 53 49.07 53.98 46,735,932
Sellers 32 -6.20 3.93 -3,398,819
Net -- 42.87 50.05 43,337,113

Concentration

Value ($MM) % O/S Shares
Total Inst. 68.80 66.58 57,648,113
Top 10 Inst. 62.06 60.28 52,191,222
Top 20 Inst. 65.43 63.98 55,400,556
Top 50 Inst. 68.47 66.21 57,331,463

Style

Holders Value ($MM) % Inst Shares Shares
Growth 12 0.58 0.63 548,720
Core Growth 10 0.51 0.56 485,865
Growth 2 0.07 0.07 62,855
Income 3 0.17 0.19 166,349
Income Value 2 0.17 0.19 161,349
Yield 1 0.01 0.01 5,000
Index 14 8.47 9.32 8,071,174
Other 34 55.56 52.79 45,711,685
Broker Dealer 12 0.46 0.50 434,017
GARP 8 0.89 0.97 842,546
Hedge Fund 9 8.18 8.99 7,786,268
Specialty 1 -- -- 336
VC/Private Equi 4 46.04 42.33 36,648,518
Value 8 0.40 0.44 385,023
Core Value 6 0.12 0.13 115,855
Deep Value 2 0.28 0.31 269,168

Location: Global Region

Holders % O/S Shares Share Change
North America 77 63.47 54,952,553 45,510,186
Europe 4 0.33 289,668 190,506

Top Holders

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 25,000,000 28.87 25,000,000 3/31/18
Vivo Capital, LLC 8,180,000 9.45 8,180,000 3/31/18
BVF Partners L.P. 5,000,000 5.77 5,000,000 3/31/18
BlackRock Institutional Trust Company, N.A. 3,592,725 4.15 2,244,816 3/31/18
The Vanguard Group, Inc. 2,244,275 2.59 1,418,427 3/31/18
GlaxoSmithKline Plc 2,121,668 2.45 -- 1/19/18
Polaris Venture Partners 1,968,606 2.27 -- 3/31/18
Alyeska Investment Group, L.P. 1,834,804 2.12 1,834,804 3/31/18
Skyline Ventures 1,499,912 1.73 -492,503 3/31/17
Northern Trust Investments, Inc. 749,232 0.87 467,355 3/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
iShares Russell 2000 ETF 1,790,576 2.07 -7,824 4/30/18
Vanguard Total Stock Market Index Fund 846,497 0.98 -340,180 4/30/18
Vanguard Extended Market Index Fund 751,470 0.87 21,700 4/30/18
iShares Russell 2000 Growth ETF 582,900 0.67 12,980 4/30/18
CREF Stock Account 243,213 0.28 159,800 3/31/18
Fidelity Large Cap Stock Fund 214,387 0.25 -186 3/31/18
iShares Micro-Cap ETF 164,443 0.19 41,884 4/30/18
Fidelity Extended Market Index Fund 157,873 0.18 60,385 3/31/18
Fidelity Advisor Capital Development Fund 144,100 0.17 -- 3/31/18
AXA 2000 Managed Volatility Portfolio 116,872 0.13 75,605 3/31/18

* Insider values reflect direct beneficial ownership.

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