Ownership Profile

Ownership Profile

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 70 46.89 59.17 51,256,837
Mutual Fund 35 2.68 3.43 2,972,811
Insider 2 0.30 0.14 122,178

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 33 10.91 12.09 10,477,071
Sellers 44 -5.72 7.44 -6,446,019
Net -- 5.19 4.65 4,031,052

Concentration

Value ($MM) % O/S Shares
Total Inst. 46.89 59.17 51,256,837
Top 10 Inst. 43.75 55.52 48,091,575
Top 20 Inst. 45.60 57.70 49,984,253
Top 50 Inst. 46.77 59.08 51,177,927

Style

Holders Value ($MM) % Inst Shares Shares
Growth 10 0.42 0.48 415,735
Core Growth 9 0.41 0.47 405,585
Growth 1 0.01 0.01 10,150
Income 3 0.02 0.03 27,274
Income Value 2 0.02 0.03 22,274
Yield 1 -- 0.01 5,000
Index 9 4.57 5.07 4,391,563
Other 29 39.25 50.33 43,598,576
Broker Dealer 8 0.33 0.36 314,423
GARP 5 0.38 0.43 369,791
Hedge Fund 13 8.08 8.96 7,765,756
VC/Private Equi 3 30.46 40.58 35,148,606
Value 5 0.04 0.04 38,490
Core Value 4 0.04 0.04 35,851
Deep Value 1 -- -- 2,639

Location: Global Region

Holders % O/S Shares Share Change
North America 59 56.03 48,535,218 6,187,302
Europe 5 0.41 355,346 341,499

Top Holders

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 25,000,000 28.86 -- 6/30/18
Vivo Capital, LLC 8,180,000 9.44 -- 6/30/18
BVF Partners L.P. 5,000,000 5.77 5,000,000 3/31/18
The Vanguard Group, Inc. 2,244,275 2.59 1,418,427 3/31/18
GlaxoSmithKline Plc 2,121,668 2.45 -- 1/19/18
Polaris Venture Partners 1,968,606 2.27 -- 3/31/18
Alyeska Investment Group, L.P. 1,834,804 2.12 1,834,804 3/31/18
Northern Trust Investments, Inc. 749,232 0.86 467,355 3/31/18
State Street Global Advisors (US) 632,135 0.73 261,200 3/31/18
Geode Capital Management, L.L.C. 360,855 0.42 176,734 3/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 1,225,285 1.41 38,608 6/30/18
Vanguard Extended Market Index Fund 751,470 0.87 21,700 6/30/18
CREF Stock Account 243,213 0.28 159,800 3/31/18
Fidelity Small Cap Index Fund 166,761 0.19 114,492 4/30/18
Fidelity Extended Market Index Fund 157,873 0.18 -- 6/30/18
Vanguard Institutional Total Stock Market Index Fund 129,073 0.15 93,284 6/30/18
Fidelity Total Market Index Fund 59,471 0.07 27,439 6/30/18
apo Medical Opportunities Institutionell 53,358 0.06 53,358 6/30/18
iShares Russell 2000 Small-Cap Index Fund 52,290 0.06 35,524 3/31/18
CREF Equity Index Account 20,661 0.02 -- 3/31/18

* Insider values reflect direct beneficial ownership.

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